Dr David McGrath

Spine Physician

MB BS (Hons) FAFOM, RACP, FAFMM
Master of Pain Medicine

	Neuro/ Transmitters (nerve-nerve)	Hormones (nerve-cell) Neuro-Endocrine	Cytokines (cell-cell)	Eicosanoids (cell-cell) (intracell)	Plasma Proteins (extracellular cascade)
Creation (Bio/Synthesis)	Axon Synthesis	Cytoplasmic	Local Tissue Cytoplasm (glucose +proteins)	Membrane Lipids (EFA's)	Liver ER Biosynthesis (AA's)
Destruction (Decomposition)	Neuro Reuptake Recycling	Liver Kidney Metabolism	Local Liver Kidney	Local	Amino Acid Pool
Sensory Receptors	Cell Membranes	Cell Membranes Nuclear Membranes	Cell Membranes Nuclear Membranes	Membranes Cytoplasm	Proteolytic Cascades
Chemical Behaviour	Action Potentials	Transcription Translation	Transcription Translation	Cytoplasmic Reactions	Immunology Clotting Anti-Clotting Vascular- Reactivity
Field Of Action	Synaptic Space Paracrine	Endocrine	Paracrine Autocrine Ectocrine Endocrine	Paracrine Autocrine	Autocrine Paracrine
Half Life	Short	Long	Long	Short	Short
Motor Redundancy (Convergence)	No	No	Yes	No	NO
Motor Pleiotropy (Divergence)	No	No	Yes	No	NO
Storage & Secretion	Terminal Vesicles	Hormone Glandular Tissue	No	No	Plasma Pool
Transport Mechanisms	Diffusion synaptic gap	Plasma apoproteins	Plasma	apoproteins	cytoplasm
Chemical Transformations	Sodium Ion Channels	Nuclear Reactions	Cytoplasm Downstream	Yes	Cascade Sequence
Negative Feedback Loops	No	Yes	Yes	Yes	No
Chemical Nature	1. Small Molecules 2.Peptides	1.Peptides 2.Steroids	1.Glyco/ proteins	Eicosanoids	Peptides Proteins

(to be continued)